NANOMEDICINE: FROM HIGH TECH TO GLOBAL HEALTH
Prof. Robert K. Prud’homme
Dept. of Chemical and Biological Engineering, Princeton University
Nanotechnology in drug delivery has a schizophrenic dichotomy of goals. One goal is to make drugs more bioavailable, which is normally associated with oral drug delivery. This bioavailability is associated with rapidly releasing drugs. The goal is achieved by making nanocarriers (NCs) with high surface-to-volume ratios, and with the drug in an amorphous state. The other goal is to encapsulate and deliver drugs to specific disease sites. This requires retaining the drug in the NC until targeted delivery is achieved. We will discuss examples of nanoparticle formulations based on our rapid micromixing platform – Flash NanoPrecipitation (FNP)– that address both of these goals. The scalability of the FNP platform has allowed it to be applied to formulate a wide range of therapeutics from small molecules, to peptides, proteins and RNA. The 253 million doses of Pfizer LNP COVID vaccine were manufactured using our FNP platform. In addition, the technology is being sponsored by the Bill and Melinda Gates Foundation to produce low-cost oral formulations of highly hydrophobic compounds for global health.. The fundamental processes involved in the kinetically controlled precipitations will be presented. In addition, post-processing including tangential flow ultrafiltration (TFF), spray drying and lyophilization of NCs will be presented. The new platform, inverse-FNP enables the encapsulation of soluble peptides, proteins and RNA at higher loadings than can be achieved with any other process.
Date and Location
May 19th, 2022
About the speaker
Robert K. Prud'homme is Professor of Chemical and Biological Engineering at Princeton University.
Ph.D., University of Wisconsin, 1978
Special Studies, Environmental Science and Public Policy, Harvard University, 1973
B.S., Stanford University, 1969
His work focuses on how weak forces at the molecular level determine macroscopic properties at larger length scales. His group spends equal time understanding the details of molecular-level interactions using NMR, neutron scattering, x-ray scattering, or electron microscopy and making measurements of bulk properties such as rheology, diffusion of proteins in gels, drop sizes of sprays, or pressure drop measurements in porous media. Their work is highly interdisciplinary; many of the projects involve joint advisors and collaborations with researchers at NIH, Argonne National Labs, CNRS in France, or major corporate research.
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