2018 Graduate Scholarship Awards

Graduate students in pharmaceutics from around the tri-state area will present their research, and scholarships will be awarded to the authors of the best posters

and keynote presentation

Thin Films for Pediatric Formulations with Metered Dosing Capabilities

Prof. Rajesh N. Davé (NJIT)

 LINK TO PRESENTATION

Polymer thin films loaded with drugs have garnered significant attention for their potential for patient compliance and continuous manufacturing. Recent work from our group and elsewhere has shown that apart from their patient compliance, they are also an ideal platform for precision or metered dosage delivery. That is due to two-dimensional format and high potential for excellent drug content uniformity per area, achievable if formulated and manufactured properly. In contrast to belief that they are only suitable for very low dosage and must be formed using drug solutions, our work has shown that this form is ideally suited to delivery of very poorly water-soluble drugs. By incorporating drug in form of engineered nano and micro sized particles, the drug dissolution rate is enhanced by preserving the high surface area through uniform particle dispersion and size/form control. The robustness of this approach is demonstrated using multiple BCS Class II drugs where the drug as a stable suspension or in dry micronized powder form may be mixed with film-forming polymeric solutions and then caste as films and dried to form stabilized drug nano or micro composite structures. It is shown that the film matrix may be designed to impart desired functionality to the final product. Examples are included to show film formed using nanosuspensions produced from wet stirred media milling (WSMM), liquid-antisolvent precipitation, melt-emulsion solid particle formation, as well as dry jet milled powders with surface modification. Overall, the films exhibited very good mechanical properties, improved drug content uniformity, and achieved fast drug dissolution. This presentation will highlight some of these results with a hope that they set the foundation for continuously operating process development of films along with flexible dosage dispensing for pediatric drug delivery applications.

 

Date and Location

Thurs May 17th, 2018 Registration & poster viewing: 5:00 PM Dinner, keynote presentation & scholarship awards: 6:30 PM (Note the earlier-than-usual start time)

Meeting Sponsors Ashland BMS Gattefossé JRS Pharma

Hanover Marriott 1401 Rt 10 East, Whippany, NJ 07981

Registration Fees

• Registered and paid online:     $50.00
• Walk-in:     $65.00
• Between-positions, Retirees & Students (WITH ADVANCE REGISTRATION ONLY):     $45.00

Advance registration will end at 5:00 PM on WEDNESDAY MAY 16th;  after that, you must pay at the door.  Note also that if you choose the "Register Now and Pay at Meeting" option, you must proceed all the way to the "Your Order is Confirmed" screen or your registration will not be recorded.

Note: in the event a meeting needs to be cancelled due to weather or other conditions, NJPhAST will do its best to notify all registrants as soon as possible; however, we ask that you exercise individual judgement if you do not hear directly from NJPhAST.