SMEDDS for Oral Delivery of Peptides: Ion-Pairing Technique for High Payload - Jasmine Musakhanian (Gattefosse)

SMEDDS for Oral Delivery of Peptides: Ion-Pairing Technique for High Payload - Jasmine Musakhanian (Gattefosse)

Jasmine Musakhanian, MS (Gattefossé USA)

LINK TO PRESENTATION

Oral administration of peptides is challenged by a number of physiological barriers including presystemic degradation by proteases; deactivation by reduced glutathione and poor intestinal membrane permeability. Lipid formulations, notably self-emulsifying drug delivery systems (SEDDS) can successfully overcome these challenges.

In an interesting series of recently published works, model peptides leuprorelin, insulin and desmopressin were formulated in SEDDS following hydrophobic ion-pairing of the peptides. The newly designed formulations facilitated payloads of >10% for peptide drugs; provided 100% protection against proteases; reduced glutathione; and improved their intestinal permeability.

This session shares the intricacies and the promising results of the aforesaid work.

 

Date and Location

Thurs Oct 19th, 2017

Registration: 5:30 PM
Dinner & Presentation: 6:30 PM

Meeting Sponsors

 Kerry

 

 

Parsippany Hilton

  • 1 Hilton Court,
  • Parsippany, NJ 07054
  • About the speaker

    Jasmine is Scientific & Marketing Director at the Pharmaceutical Division of Gattefossé USA. Her multi-disciplinary career has revolved around excipients, notably their safety, quality, and applications in drug delivery. Special areas of interest to her are lipid-based solubilization technologies for enhancing the delivery of challenging molecules. She is author of technical and scientific reviews; active member of the AAPS; and resides on USP Expert Committees for excipient functionality and monograph modernization. Jasmine graduated from McGill University in Montreal with B.Sc. (Food Science) and M.Sc. (Protein Chemistry). Her résumé includes a variety of technical liaison positions at McGill University; Seiko Scientific Instruments; Ashland Chemical; Daminco Inc.; and Gattefossé, the latter since 1997.

    Registration Fees

    • Registered and paid online:     $50.00
    • Walk-in:     $65.00
    • Between-positions, Retirees & Students (WITH ADVANCE REGISTRATION ONLY):     $45.00

    ADVANCE REGISTRATION WILL END AT 5:00 PM ON TUESDAY OCT 17th;  AFTER THAT YOU MUST PAY AT THE DOOR.

    Please Fill Out The Form

    Regular Vegetarian

    Regular price $50.00 Sale